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    unc-75 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-75
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00006807
    Locus tag
    CELE_C17D12.2
    See related
    AllianceGenome:WB:WBGene00006807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in neurons and pharyngeal gland cell. Orthologous to several human genes including CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-75 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (11592246..11601712)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sperm transmembrane protein 9 Neighboring gene UBC core domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PeriCentriolar MatriX Deficient Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Kuroyanagi H, et al. Nucleic Acids Res, 2013 Apr. PMID 23416545, Free PMC Article
    2. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans. Koterniak B, et al. Genome Res, 2020 Dec. PMID 33127752, Free PMC Article
    3. A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types. Norris AD, et al. Mol Cell, 2014 Jun 19. PMID 24910101, Free PMC Article
    4. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. Kuroyanagi H, et al. PLoS Genet, 2013. PMID 23468662, Free PMC Article
    5. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Chen L, et al. Elife, 2016 Jun 2. PMID 27253061, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans.
      Title: Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans.
    2. this study identifies two conserved RNA-binding proteins, UNC-75/CELF and EXC-7/Hu/ELAV, which regulate overlapping networks of splicing events in GABAergic and cholinergic neurons.
      Title: A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types.
    3. The results indicate that UNC-75 regulates alternative splicing of its target exons in neuron-specific and position-dependent manners through the (G/U)UGUUGUG elements in C. elegans.
      Title: Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans.
    4. Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene.
      Title: CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001300407.1
    • Confirmed by transcript evidence
    NP_001300408.1
    • Confirmed by transcript evidence
    NP_001300409.1
    • Partially confirmed by transcript evidence
    NP_492958.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11592246..11601712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060557.7 → NP_492958.3  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492958.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE68
      Conserved Domains (3) summary
      cd12632
      Location:24 → 110
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:425 → 503
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:123 → 203
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001313478.3 → NP_001300407.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWH2
      Conserved Domains (2) summary
      cd12632
      Location:24 → 110
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:123 → 203
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001313479.3 → NP_001300408.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR68
      Conserved Domains (2) summary
      cd12639
      Location:327 → 405
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:25 → 105
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001313480.3 → NP_001300409.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATM0
      Conserved Domains (1) summary
      cl17169
      Location:25 → 105
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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