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    rbm-25 PWI domain-containing protein;RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbm-25
    Official Full Name
    PWI domain-containing protein;RRM domain-containing protein
    Primary source
    WormBase:WBGene00012245
    Locus tag
    CELE_W04D2.6
    See related
    AllianceGenome:WB:WBGene00012245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rbm-25 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (12498213..12503708)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Innexin;Innexin-11 Neighboring gene Ribosomal protein S11 Neighboring gene C2H2-type domain-containing protein Neighboring gene L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation. Fortes P, et al. FEBS Lett, 2007 Jun 26. PMID 17560998
    2. Synaptic protein UNC-13 interacts with an F-box protein that may target it for degradation by proteasomes. Polinsky C, et al. Acta Biochim Pol, 2006. PMID 16496042
    3. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    4. Robust regulatory architecture of pan-neuronal gene expression. Leyva-Díaz E, et al. Curr Biol, 2022 Apr 25. PMID 35259341, Free PMC Article
    5. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PWI domain-containing protein;RRM domain-containing protein
    NP_001256427.1
    • Confirmed by transcript evidence
    NP_506133.2
    • Confirmed by transcript evidence
    NP_506134.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12498213..12503708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269498.3 → NP_001256427.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2D0
      Conserved Domains (4) summary
      PTZ00121
      Location:116 → 449
      PTZ00121; MAEBL; Provisional
      smart00311
      Location:628 → 701
      PWI; domain in splicing factors
      COG4372
      Location:300 → 452
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd12446
      Location:49 → 129
      RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins

    2. NM_073732.8 → NP_506133.2  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506133.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE97
      Conserved Domains (3) summary
      PTZ00121
      Location:116 → 451
      PTZ00121; MAEBL; Provisional
      smart00311
      Location:626 → 699
      PWI; domain in splicing factors
      cd12446
      Location:49 → 129
      RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins

    3. NM_073733.6 → NP_506134.3  PWI domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506134.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4F3
      Conserved Domains (2) summary
      PTZ00121
      Location:101 → 245
      PTZ00121; MAEBL; Provisional
      smart00311
      Location:420 → 493
      PWI; domain in splicing factors
    Nucleotide Protein
    Heading Accession and Version

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