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    ubq-2 Ubiquitin [ Caenorhabditis elegans ]

    Gene ID: 176718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubq-2
    Official Full Name
    Ubiquitin
    Primary source
    WormBase:WBGene00006728
    Locus tag
    CELE_ZK1010.1
    See related
    AllianceGenome:WB:WBGene00006728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in polarity specification of anterior/posterior axis. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; pharyngeal-intestinal valve; pharynx; and somatic nervous system. Orthologous to human UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ubq-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (12977963..12978523, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 2-oxoisovalerate dehydrogenase subunit alpha;2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial Neighboring gene DUF155 domain-containing protein Neighboring gene Protein FRG1 homolog Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A portable regulatory element directs specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2 in the somatic gonad. Jones D, et al. Dev Biol, 1995 Sep. PMID 7556908
    2. Screening and analysis of Hc-ubq and Hc-gst related to desiccation survival of infective Haemonchus contortus larvae. Yang Y, et al. Vet Parasitol, 2015 Jun 15. PMID 25913452
    3. The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains. Pluska L, et al. EMBO J, 2021 Mar 15. PMID 33576509, Free PMC Article
    4. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Rappleye CA, et al. Dev Cell, 2002 Feb. PMID 11832245
    5. Anaphase-promoting complex in Caenorhabditis elegans. Yeong FM. Mol Cell Biol, 2004 Mar. PMID 14993261, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin
    NP_499695.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12977963..12978523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067294.6 → NP_499695.1  Ubiquitin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14792, P49632, Q9U1P3
      Conserved Domains (3) summary
      cd01803
      Location:1 → 76
      Ubiquitin; Ubiquitin
      smart00213
      Location:1 → 72
      UBQ; Ubiquitin homologues
      pfam01020
      Location:78 → 126
      Ribosomal_L40e; Ribosomal L40e family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49632.2

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