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    wdr-5.2 WD repeat-containing protein wdr-5.2 [ Caenorhabditis elegans ]

    Gene ID: 181540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr-5.2
    Official Full Name
    WD repeat-containing protein wdr-5.2
    Primary source
    WormBase:WBGene00010572
    Locus tag
    CELE_K04G11.4
    See related
    AllianceGenome:WB:WBGene00010572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein complex binding activity and microtubule plus-end binding activity. Predicted to be involved in several processes, including brain morphogenesis; microtubule cytoskeleton organization; and transport along microtubule. Predicted to be located in axon cytoplasm. Predicted to be part of microtubule associated complex. Predicted to be active in several cellular components, including cytoplasmic microtubule; kinetochore; and neuronal cell body. Is expressed in several structures, including intestine; nervous system; pharynx; spermatheca; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wdr-5.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (14350118..14352873)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Putative transcription factor sel-7 Neighboring gene Secreted protein Neighboring gene RSD-2 N-terminal domain-containing protein Neighboring gene IRK_C domain-containing protein;Inward rectifier potassium channel C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans. Li T, et al. Nucleic Acids Res, 2014 May. PMID 24682813, Free PMC Article
    2. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
    3. Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels. Petty E, et al. PLoS One, 2011. PMID 21998734, Free PMC Article
    4. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Ziegler K, et al. Cell Host Microbe, 2009 Apr 23. PMID 19380113
    5. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein wdr-5.2
    NP_510394.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14350118..14352873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077993.5 → NP_510394.1  WD repeat-containing protein wdr-5.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93847
      Conserved Domains (4) summary
      COG2319
      Location:104 → 395
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:106 → 392
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]
      cl23807
      Location:1 → 87
      WWbp; WW-domain ligand protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93847.1

    Gene LinkOut

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