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    mrp-2 Multidrug resistance-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrp-2
    Official Full Name
    Multidrug resistance-associated protein 1
    Primary source
    WormBase:WBGene00003408
    Locus tag
    CELE_F57C12.4
    See related
    AllianceGenome:WB:WBGene00003408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 77; bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mrp-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (563711..572701, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene BHLH domain-containing protein Neighboring gene Zinc metalloproteinase nas-38 Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene Bromo domain-containing protein Neighboring gene Neuropeptide-Like Protein;Peptidase_M13 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of ABC transporters acting in vitamin B(12) metabolism in Caenorhabditis elegans. McDonald MK, et al. Mol Genet Metab, 2017 Dec. PMID 29153845
    2. Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model. Tedesco P, et al. PLoS One, 2015. PMID 26587842, Free PMC Article
    3. Turn to the worm! Ahringer J. Curr Opin Genet Dev, 1997 Jun. PMID 9229119
    4. Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. Broeks A, et al. EMBO J, 1996 Nov 15. PMID 8947035, Free PMC Article
    5. Global analysis of dauer gene expression in Caenorhabditis elegans. Wang J, et al. Development, 2003 Apr. PMID 12620986

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Multidrug resistance-associated protein 1
    NP_508121.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      563711..572701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075720.7 → NP_508121.1  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20943, Q94137
      Conserved Domains (5) summary
      TIGR00957
      Location:25 → 1522
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1284 → 1504
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 816
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:971 → 1239
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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