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    piga-1 PIGA GPI anchor biosynthesis domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    piga-1
    Official Full Name
    PIGA GPI anchor biosynthesis domain-containing protein
    Primary source
    WormBase:WBGene00008431
    Locus tag
    CELE_D2085.6
    See related
    AllianceGenome:WB:WBGene00008431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See piga-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8659782..8661712, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Integrase Neighboring gene Glutamine-dependent carbamoyl-phosphate synthase Neighboring gene Translation initiation factor eIF2B subunit epsilon Neighboring gene Ubiquitin-like-conjugating enzyme ATG10 Neighboring gene E3 ubiquitin-protein ligase etc-1 Neighboring gene Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans. Murata D, et al. Mol Biol Cell, 2012 Mar. PMID 22298425, Free PMC Article
    2. Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis. Budirahardja Y, et al. PLoS Genet, 2015 Mar. PMID 25807459, Free PMC Article
    3. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis. Ihara S, et al. J Cell Sci, 2017 Feb 1. PMID 27980068
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PIGA GPI anchor biosynthesis domain-containing protein
    NP_495840.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8659782..8661712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063439.7 → NP_495840.1  PIGA GPI anchor biosynthesis domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18993
      Conserved Domains (1) summary
      cd03796
      Location:9 → 408
      GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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