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    gpdh-2 Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2 [ Caenorhabditis elegans ]

    Gene ID: 176399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpdh-2
    Official Full Name
    Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2
    Primary source
    WormBase:WBGene00010778
    Locus tag
    CELE_K11H3.1
    See related
    AllianceGenome:WB:WBGene00010778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glycerol-3-phosphate dehydrogenase (NAD+) activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in intracellular accumulation of glycerol. Predicted to be located in cytoplasm. Predicted to be part of glycerol-3-phosphate dehydrogenase (FAD) complex. Predicted to be active in cytosol. Is expressed in several structures, including body wall musculature; excretory cell; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1) and GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpdh-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (9854074..9859183, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative tricarboxylate transport protein, mitochondrial Neighboring gene Potassium channel domain-containing protein Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Burton NO, et al. Nat Cell Biol, 2017 Mar. PMID 28166192, Free PMC Article
    2. Inheritance of protection from osmotic stress. Kaneshiro KR, et al. Nat Cell Biol, 2017 Mar 1. PMID 28248305
    3. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. Lamitina ST, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14644776
    4. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Possik E, et al. PLoS Genet, 2015 Oct. PMID 26439621, Free PMC Article
    5. Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans. Rohlfing AK, et al. PLoS One, 2010 Feb 2. PMID 20126308, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular accumulation of glycerol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glycerol-3-phosphate dehydrogenase [NAD(+)];putative glycerol-3-phosphate dehydrogenase 2
    NP_001122709.1
    • Confirmed by transcript evidence
    NP_001122710.1
    • Confirmed by transcript evidence
    NP_499188.2
    • Confirmed by transcript evidence
    NP_871632.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9854074..9859183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066787.7 → NP_499188.2  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499188.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMU1
      Conserved Domains (3) summary
      TIGR03376
      Location:25 → 364
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:25 → 196
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:219 → 357
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    2. NM_181903.7 → NP_871632.1  putative glycerol-3-phosphate dehydrogenase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34517, Q8I4H2
      Conserved Domains (3) summary
      TIGR03376
      Location:37 → 385
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:37 → 217
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:240 → 378
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    3. NM_001129237.4 → NP_001122709.1  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE5
      Conserved Domains (3) summary
      TIGR03376
      Location:5 → 297
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam07479
      Location:152 → 290
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
      cl21454
      Location:5 → 129
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_001129238.4 → NP_001122710.1  Glycerol-3-phosphate dehydrogenase [NAD(+)] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPE6
      Conserved Domains (3) summary
      TIGR03376
      Location:5 → 353
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:5 → 185
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:208 → 346
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34517.2

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