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    ntl-4 CCR4-NOT transcription complex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 177580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ntl-4
    Official Full Name
    CCR4-NOT transcription complex subunit 4
    Primary source
    WormBase:WBGene00003827
    Locus tag
    CELE_C49H3.5
    See related
    AllianceGenome:WB:WBGene00003827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ntl-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (7910575..7915189)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Bifunctional purine biosynthesis protein ATIC;Phosphoribosylaminoimidazolecarboxamide formyltransferase Neighboring gene Actin-related protein 10 Neighboring gene Cortactin-binding protein-2 N-terminal domain-containing protein Neighboring gene C3HC-type domain-containing protein Neighboring gene Sm domain-containing protein Neighboring gene Exportin-T Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans. Nousch M, et al. J Cell Sci, 2013 Sep 15. PMID 23843623
    2. Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans. Venz R, et al. G3 (Bethesda), 2020 Nov 5. PMID 32958476, Free PMC Article
    3. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    4. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 4
    NP_001294150.1
    • Confirmed by transcript evidence
    NP_001294151.1
    • Confirmed by transcript evidence
    NP_001294152.1
    • Confirmed by transcript evidence
    NP_741453.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7910575..7915189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307222.3 → NP_001294151.1  CCR4-NOT transcription complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RTE4
      Conserved Domains (2) summary
      cd12438
      Location:103 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    2. NM_001307221.3 → NP_001294150.1  CCR4-NOT transcription complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RRU8
      Conserved Domains (2) summary
      cd12438
      Location:103 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    3. NM_001307223.3 → NP_001294152.1  CCR4-NOT transcription complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBC7
      Conserved Domains (2) summary
      cd12438
      Location:103 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    4. NM_171388.7 → NP_741453.1  CCR4-NOT transcription complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYQ9
      Conserved Domains (2) summary
      cd12438
      Location:103 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:13 → 59
      zf-RING_4; RING/Ubox like zinc-binding domain

    RNA

    1. NR_131578.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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