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    fubl-2 K Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fubl-2
    Official Full Name
    K Homology domain-containing protein
    Primary source
    WormBase:WBGene00022738
    Locus tag
    CELE_ZK418.9
    See related
    AllianceGenome:WB:WBGene00022738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KHSRP (KH-type splicing regulatory protein); FUBP1 (far upstream element binding protein 1); and FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fubl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (7085196..7087741, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene K Homology domain-containing protein Neighboring gene NR LBD domain-containing protein Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of proteins and miRNAs that specifically bind an mRNA in vivo. Theil K, et al. Nat Commun, 2019 Sep 16. PMID 31527589, Free PMC Article
    2. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein
    NP_001023000.1
    • Confirmed by transcript evidence
    NP_001370316.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7085196..7087741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027829.5 → NP_001023000.1  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23487
      Conserved Domains (4) summary
      smart00322
      Location:52 → 122
      KH; K homology RNA-binding domain
      cd00105
      Location:243 → 304
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:139 → 204
      KH_1; KH domain
      pfam09005
      Location:498 → 533
      DUF1897; Domain of unknown function (DUF1897)

    2. NM_001382907.2 → NP_001370316.1  K Homology domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z145
      Conserved Domains (3) summary
      pfam09005
      Location:451 → 486
      DUF1897; Domain of unknown function (DUF1897)
      cd22398
      Location:194 → 261
      KH-I_FUBP_rpt3; third type I K homology (KH) RNA-binding domain found in the FUBP family RNA/DNA-binding proteins
      cl00098
      Location:92 → 161
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein
    Heading Accession and Version

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