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    ceh-2 Homeobox protein ceh-2 [ Caenorhabditis elegans ]

    Gene ID: 191615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-2
    Official Full Name
    Homeobox protein ceh-2
    Primary source
    WormBase:WBGene00000429
    Locus tag
    CELE_C27A12.5
    See related
    AllianceGenome:WB:WBGene00000429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in head; neurons; pharynx; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to several human genes including EMX1 (empty spiracles homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (6046788..6050451, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression in vitro of a gene encoding tRNAArgACG from the nematode Caenorhabditis elegans. Schaller D, et al. Gene, 1991 Jan 15. PMID 1999292
    2. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Aspöck G, et al. Development, 2003 Aug. PMID 12810585
    3. Gene expression markers for Caenorhabditis elegans vulval cells. Inoue T, et al. Mech Dev, 2002 Dec. PMID 14516686
    4. Caenorhabditis elegans has scores of homoeobox-containing genes. Bürglin TR, et al. Nature, 1989 Sep 21. PMID 2571091
    5. Transcriptional network underlying Caenorhabditis elegans vulval development. Inoue T, et al. Proc Natl Acad Sci U S A, 2005 Apr 5. PMID 15749820, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-2
    NP_491746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6046788..6050451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059345.7 → NP_491746.1  Homeobox protein ceh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECT8
      Conserved Domains (1) summary
      pfam00046
      Location:130 → 182
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECT8.1

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