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    unc-93 Putative potassium channel regulatory protein unc-93 [ Caenorhabditis elegans ]

    Gene ID: 175466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-93
    Official Full Name
    Putative potassium channel regulatory protein unc-93
    Primary source
    WormBase:WBGene00006822
    Locus tag
    CELE_C46F11.1
    See related
    AllianceGenome:WB:WBGene00006822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Is expressed in SIA; body wall musculature; and non-striated muscle. Orthologous to human UNC93A (unc-93 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-93 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (3644375..3648822)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RILP-like protein 1 Neighboring gene ncRNA Neighboring gene MADF domain-containing protein Neighboring gene Glutathione reductase, mitochondrial Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of Caenorhabditis elegans genomic DNA and detection of deletions in the unc-93 gene using PCR. Lissemore JL, et al. Biochem Mol Biol Educ, 2005 May. PMID 21638583
    2. Characterization of revertants of unc-93(e1500) in Caenorhabditis elegans induced by N-ethyl-N-nitrosourea. De Stasio E, et al. Genetics, 1997 Oct. PMID 9335597, Free PMC Article
    3. Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo. Ma L, et al. PLoS Genet, 2009 Nov. PMID 19893607, Free PMC Article
    4. sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. de la Cruz IP, et al. J Neurosci, 2003 Oct 8. PMID 14534247, Free PMC Article
    5. Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans. Greenwald IS, et al. Genetics, 1982 Jun. PMID 7173602, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that loss-of-function mutations in the nonessential splicing factor smu-2 and smu-1 suppress unc-73 e936 uncoordination through changes in splicing.
      Title: A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Putative potassium channel regulatory protein unc-93
    NP_001021218.1
    • Partially confirmed by transcript evidence
    NP_001366876.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3644375..3648822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026047.5 → NP_001021218.1  Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021218.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23024, Q23025, Q58A93, Q7JN54, Q7JN55, Q93380
      Conserved Domains (2) summary
      cd06174
      Location:250 → 673
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:250 → 643
      MFS_1; Major Facilitator Superfamily

    2. NM_001381807.1 → NP_001366876.1  Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd17406
      Location:245 → 673
      MFS_unc93A_like; Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93380.4

    Gene LinkOut

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