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    grd-2 Ground-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grd-2
    Official Full Name
    Ground-like domain-containing protein
    Primary source
    WormBase:WBGene00001691
    Locus tag
    CELE_F46B3.5
    See related
    AllianceGenome:WB:WBGene00001691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cholesterol binding activity; endopeptidase activity; and signaling receptor binding activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in excretory duct and excretory pore. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal (multiple); Hirschsprung's disease; bone development disease (multiple); holoprosencephaly (multiple); and hypoplastic or aplastic tibia with polydactyly. Orthologous to human IHH (Indian hedgehog signaling molecule); DHH (desert hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See grd-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (20609794..20613929)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TransThyretin-Related family domain Neighboring gene Neuropeptide-Like Protein Neighboring gene TransThyretin-Related family domain Neighboring gene pseudo Neighboring gene DUF281 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
    2. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520
    3. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao L, et al. BMC Genomics, 2006 Oct 31. PMID 17076889, Free PMC Article
    4. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
    5. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. Bürglin TR. BMC Genomics, 2008 Mar 11. PMID 18334026, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ground-like domain-containing protein
    NP_507977.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20609794..20613929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075576.4 → NP_507977.2  Ground-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507977.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XV14
      Conserved Domains (2) summary
      cd00081
      Location:742 → 889
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam04155
      Location:41 → 118
      Ground-like; Ground-like domain
    Nucleotide Protein
    Heading Accession and Version

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