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    eppl-1 Ethanolamine-phosphate phospho-lyase homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 177646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eppl-1
    Official Full Name
    Ethanolamine-phosphate phospho-lyase homolog 1
    Primary source
    WormBase:WBGene00020139
    Locus tag
    CELE_T01B11.2
    See related
    AllianceGenome:WB:WBGene00020139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lyase activity; pyridoxal phosphate binding activity; and transaminase activity. Is expressed in PQR; amphid neurons; hypodermis; intestine; and pharynx. Orthologous to human PHYKPL (5-phosphohydroxy-L-lysine phospho-lyase) and ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eppl-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (8449353..8451759, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative syntaxin-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Expanded Role for the RFX Transcription Factor DAF-19, with Dual Functions in Ciliated and Nonciliated Neurons. De Stasio EA, et al. Genetics, 2018 Mar. PMID 29301909, Free PMC Article
    2. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ethanolamine-phosphate phospho-lyase homolog 1
    NP_001023346.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8449353..8451759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028175.7 → NP_001023346.1  Ethanolamine-phosphate phospho-lyase homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91408
      Conserved Domains (2) summary
      cd00610
      Location:49 → 462
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:13 → 463
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    RNA

    1. NR_131583.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91408.1

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