eor-1 C2H2-type domain-containing protein;Zinc finger protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eor-1
Official Full Name: C2H2-type domain-containing protein;Zinc finger protein
Primary source: WormBase:WBGene00001324
Locus tag: CELE_R11E3.6
See related: AllianceGenome:WB:WBGene00001324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Ras protein signal transduction; determination of adult lifespan; and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in several structures, including epithelial system; gonad; nervous system; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eor-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 15

Sequence:: Chromosome: IV; NC_003282.8 (4793194..4799178, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the interaction between EOR-1 and EOR-2
Title: EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans.
eor-1 and eor-2 function together throughout the nervous system to promote terminal differentiation of neurons and function specifically in male hermaphrodite-specific neurons to promote apoptotic death.
Title: eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R11E3.6 (e-PCR)
- UniSTS:312732

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C2H2-type domain-containing protein;Zinc finger protein

NP_001367921.1

Confirmed by transcript evidence

NP_001368235.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4793194..4799178 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380207.3 → NP_001367921.1 Zinc finger protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EDU4

Conserved Domains (6) summary

PHA03098
Location:34 → 229

PHA03098; kelch-like protein; Provisional

sd00017
Location:601 → 618

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18186
Location:41 → 118

BTB_POZ_ZBTB_KLHL-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins

pfam13465
Location:638 → 663

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:652 → 676

zf-H2C2_5; C2H2-type zinc-finger domain

pfam15909
Location:481 → 527

zf-C2H2_8; C2H2-type zinc ribbon
NM_001380208.1 → NP_001368235.1 C2H2-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PEC2

Conserved Domains (4) summary

sd00017
Location:8 → 28

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:8 → 28

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:20 → 45

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:34 → 58

zf-H2C2_5; C2H2-type zinc-finger domain