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    mtk-1 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtk-1
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00003472
    Locus tag
    CELE_B0414.7
    See related
    AllianceGenome:WB:WBGene00003472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in MAPK cascade and protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mtk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (5795400..5803734, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cytoplasmic polyadenylation element-binding protein 3 Neighboring gene ATP-dependent RNA helicase glh-3 Neighboring gene Serpentine Receptor, class Z Neighboring gene Vacuolar protein sorting-associated protein 51 homolog Neighboring gene Uncharacterized protein Neighboring gene Retinoblastoma-like protein homolog lin-35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein. Blum ES, et al. Science, 2012 Feb 24. PMID 22363008, Free PMC Article
    2. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
    3. Functional genomic analysis of RNA interference in C. elegans. Kim JK, et al. Science, 2005 May 20. PMID 15790806
    4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_001367356.1
    • Confirmed by transcript evidence
    NP_491683.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5795400..5803734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059282.5 → NP_491683.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01837
      Conserved Domains (1) summary
      cl21453
      Location:1125 → 1388
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001380377.3 → NP_001367356.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960A2
      Conserved Domains (1) summary
      cl21453
      Location:1125 → 1388
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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