ehs-1 Eps15 (endocytosis protein) Homologous Sequence [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ehs-1
Official Full Name: Eps15 (endocytosis protein) Homologous Sequence
Primary source: WormBase:WBGene00001224
Locus tag: CELE_ZK1248.3
See related: AllianceGenome:WB:WBGene00001224
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in chemical synaptic transmission and synaptic vesicle endocytosis. Located in axon; plasma membrane; and synapse. Is expressed in several structures, including coelomocyte; epithelial cell; intestine; muscle cell; and somatic nervous system. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15) and EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ehs-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (5820712..5823862)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

physical connections and of the functional wirings of the EH-network in the nematode
Title: A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZK1248.3 (e-PCR)
- UniSTS:310434

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IMP Inferred from Mutant Phenotype more info	PubMed
part_of clathrin coat of coated pit	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Eps15 (endocytosis protein) Homologous Sequence

NP_001022499.2

Product from WormBase gene class ehs;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5820712..5823862

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027328.7 → NP_001022499.2 Eps15 (endocytosis protein) Homologous Sequence [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022499.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9BIF4

Conserved Domains (4) summary

smart00027
Location:155 → 249

EH; Eps15 homology domain

cd00052
Location:166 → 231

EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

pfam12325
Location:446 → 539

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

cl23720
Location:457 → 548

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)