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    ttc-7 TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttc-7
    Official Full Name
    TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00021444
    Locus tag
    CELE_Y39A3CR.3
    See related
    AllianceGenome:WB:WBGene00021444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anal depressor muscle; coelomocyte; excretory cell; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A) and TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ttc-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (1860429..1877886)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BHLH domain-containing protein Neighboring gene Mitochondrial import inner membrane translocase subunit Tim8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gem-associated protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein
    NP_001254845.1
    • Confirmed by transcript evidence
    NP_001254846.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1860429..1877886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267916.2 → NP_001254845.1  Tetratricopeptide repeat protein 7 N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYB6
      Conserved Domains (2) summary
      TIGR02917
      Location:508 → 951
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:888 → 915
      TPR; TPR repeat [structural motif]

    2. NM_001267917.3 → NP_001254846.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F8WU09
      Conserved Domains (2) summary
      TIGR02917
      Location:112 → 555
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:412 → 440
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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