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    gex-4 GPN-loop GTPase 3 [ Caenorhabditis elegans ]

    Gene ID: 176649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gex-4
    Official Full Name
    GPN-loop GTPase 3
    Primary source
    WormBase:WBGene00013550
    Locus tag
    CELE_Y75B8A.14
    See related
    AllianceGenome:WB:WBGene00013550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Orthologous to human GPN3 (GPN-loop GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gex-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (12216779..12218634, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene titin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Golgi pH regulator Neighboring gene Geminin homolog Neighboring gene Clathrin light chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs". Matthews LR, et al. Genome Res, 2001 Dec. PMID 11731503, Free PMC Article
    2. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GPN-loop GTPase 3
    NP_499587.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12216779..12218634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067186.4 → NP_499587.1  GPN-loop GTPase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW68
      Conserved Domains (2) summary
      COG1100
      Location:2 → 203
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam03029
      Location:7 → 252
      ATP_bind_1; Conserved hypothetical ATP binding protein
    Nucleotide Protein
    Heading Accession and Version

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