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    try-5 Trypsin-like protease try-5 [ Caenorhabditis elegans ]

    Gene ID: 187088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    try-5
    Official Full Name
    Trypsin-like protease try-5
    Primary source
    WormBase:WBGene00006623
    Locus tag
    CELE_K07B1.1
    See related
    AllianceGenome:WB:WBGene00006623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Is expressed in head; male gonad; tail; uterus; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See try-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (9347044..9348685)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Target Of Splicing Neighboring gene G-patch domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A seminal fluid protease activates sperm motility in C. elegans males. Smith JR, et al. Worm, 2012 Jul 1. PMID 24058840, Free PMC Article
    2. Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility. Chavez DR, et al. Development, 2018 Dec 18. PMID 30470702, Free PMC Article
    3. SNF-10 connects male-derived signals to the onset of sperm motility in C. elegans. Fenker KE, et al. Worm, 2015 Jan-Mar. PMID 26430556, Free PMC Article
    4. Co-option of alternate sperm activation programs in the evolution of self-fertile nematodes. Wei Q, et al. Nat Commun, 2014 Dec 19. PMID 25523309
    5. Transformation: how do nematode sperm become activated and crawl? Ma X, et al. Protein Cell, 2012 Oct. PMID 22903434, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Trypsin-like protease try-5
    NP_505421.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9347044..9348685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073020.6 → NP_505421.3  Trypsin-like protease try-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505421.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01887
      Conserved Domains (1) summary
      cl21584
      Location:48 → 296
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01887.3

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