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    sra-13 Serpentine receptor class alpha-13 [ Caenorhabditis elegans ]

    Gene ID: 186058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sra-13
    Official Full Name
    Serpentine receptor class alpha-13
    Primary source
    WormBase:WBGene00005039
    Locus tag
    CELE_F49E12.5
    See related
    AllianceGenome:WB:WBGene00005039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables olfactory receptor activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in membrane. Is expressed in several structures, including amphid neurons; body wall musculature; head; hypodermis; and muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sra-13 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (8407685..8409237)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peroxidase skpo-1 Neighboring gene UBC core domain-containing protein Neighboring gene Transcription factor efl-3 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples. Lanza E, et al. Sci Rep, 2021 Aug 24. PMID 34429473, Free PMC Article
    2. The putative chemoreceptor families of C. elegans. Robertson HM, et al. WormBook, 2006 Jan 6. PMID 18050473, Free PMC Article
    3. G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity. Matúš D, et al. J Dev Biol, 2018 Nov 25. PMID 30477278, Free PMC Article
    4. Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone. Torayama I, et al. J Neurosci, 2007 Jan 24. PMID 17251413, Free PMC Article
    5. The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development. Battu G, et al. Development, 2003 Jun. PMID 12736202

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of response to food IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serpentine receptor class alpha-13
    NP_001022186.1
    • Partially confirmed by transcript evidence
    NP_001022187.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8407685..8409237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027016.3 → NP_001022187.1  Serpentine receptor class alpha-13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20618
      Conserved Domains (1) summary
      pfam02117
      Location:23 → 170
      7TM_GPCR_Sra; Serpentine type 7TM GPCR chemoreceptor Sra

    2. NM_001027015.1 → NP_001022186.1  Serpentine receptor class alpha-13 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20618, Q7JM75
      Conserved Domains (1) summary
      pfam02117
      Location:8 → 334
      7TM_GPCR_Sra; Serpentine type 7TM GPCR chemoreceptor Sra
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20618.2

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