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    meg-4 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    meg-4
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00016485
    Locus tag
    CELE_C36C9.1
    See related
    AllianceGenome:WB:WBGene00016485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in P granule assembly; germ cell proliferation; and organelle localization. Located in P granule. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See meg-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (1682954..1686419)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Transposase Neighboring gene Transposase Neighboring gene EF-hand domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote. Wu Y, et al. Mol Biol Cell, 2019 Feb 1. PMID 30540524, Free PMC Article
    2. Regulation of biomolecular condensates by interfacial protein clusters. Folkmann AW, et al. Science, 2021 Sep 10. PMID 34516789, Free PMC Article
    3. Large RNP granules in Caenorhabditis elegans oocytes have distinct phases of RNA-binding proteins. Elaswad MT, et al. G3 (Bethesda), 2022 Aug 25. PMID 35816006, Free PMC Article
    4. GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance. Chen W, et al. Nat Commun, 2022 Sep 9. PMID 36085149, Free PMC Article
    5. Germ Granules Govern Small RNA Inheritance. Lev I, et al. Curr Biol, 2019 Sep 9. PMID 31378614, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    J domain-containing protein
    NP_508310.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1682954..1686419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075909.4 → NP_508310.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508310.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZK8
    Nucleotide Protein
    Heading Accession and Version

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