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    symk-1 DUF3453 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    symk-1
    Official Full Name
    DUF3453 domain-containing protein
    Primary source
    WormBase:WBGene00017797
    Locus tag
    CELE_F25G6.2
    See related
    AllianceGenome:WB:WBGene00017797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mRNA processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See symk-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (8570311..8581745)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Acetylcholine receptor subunit alpha-type acr-16 Neighboring gene Signal recognition particle 14 kDa protein Neighboring gene Signal recognition particle 14 kDa protein Neighboring gene MULE transposase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex. Urso SJ, et al. Genetics, 2023 May 4. PMID 36972377, Free PMC Article
    2. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
    3. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUF3453 domain-containing protein
    NP_505210.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8570311..8581745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072809.7 → NP_505210.2  DUF3453 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505210.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16929
      Conserved Domains (2) summary
      pfam11935
      Location:111 → 347
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:889 → 1070
      Symplekin_C; Symplekin tight junction protein C terminal
    Nucleotide Protein
    Heading Accession and Version

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