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    gpa-18 G Protein, Alpha subunit [ Caenorhabditis elegans ]

    Gene ID: 189161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-18
    Official Full Name
    G Protein, Alpha subunit
    Primary source
    WormBase:WBGene00020997
    Locus tag
    CELE_W03F8.9
    See related
    AllianceGenome:WB:WBGene00020997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in neurons; tail; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (5189007..5195631, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene EKC/KEOPS complex subunit TPRKB Neighboring gene Activin_recp domain-containing protein;DUF3309 domain-containing protein;Secreted protein Neighboring gene Peptide chain release factor 1;putative peptide chain release factor 1, mitochondrial Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G Protein, Alpha subunit
    NP_001293718.1
    • Product from WormBase gene class gpa;
      Confirmed by transcript evidence
    NP_001293719.1
    • Product from WormBase gene class gpa;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5189007..5195631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306790.3 → NP_001293719.1  G Protein, Alpha subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLB7
      Conserved Domains (1) summary
      pfam00503
      Location:8 → 309
      G-alpha; G-protein alpha subunit

    2. NM_001306789.3 → NP_001293718.1  G Protein, Alpha subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLF3
      Conserved Domains (1) summary
      pfam00503
      Location:8 → 307
      G-alpha; G-protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version

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