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    sas-1 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sas-1
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00013742
    Locus tag
    CELE_Y111B2A.24
    See related
    AllianceGenome:WB:WBGene00013742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in centriole. Is expressed in sperm. Used to study orofaciodigital syndrome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sas-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (12699494..12711136)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UAA transporter Neighboring gene Helicase ssl-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1. Pierron M, et al. EMBO J, 2023 Dec 11. PMID 37987153, Free PMC Article
    2. SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans. von Tobel L, et al. PLoS Genet, 2014 Nov. PMID 25412110, Free PMC Article
    3. Molecular architecture of the C. elegans centriole. Woglar A, et al. PLoS Biol, 2022 Sep. PMID 36107993, Free PMC Article
    4. Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Srayko M, et al. Dev Cell, 2005 Aug. PMID 16054029
    5. Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis. Gönczy P, et al. J Cell Biol, 1999 Mar 8. PMID 10085292, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1.
      Title: Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_499651.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12699494..12711136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067250.5 → NP_499651.2  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499651.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BHL0
      Conserved Domains (1) summary
      pfam00168
      Location:371 → 467
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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