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    xrn-1 5'-3' exoribonuclease 1 [ Caenorhabditis elegans ]

    Gene ID: 175059, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xrn-1
    Official Full Name
    5'-3' exoribonuclease 1
    Primary source
    WormBase:WBGene00012730
    Locus tag
    CELE_Y39G8C.1
    See related
    AllianceGenome:WB:WBGene00012730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' RNA exonuclease activity and RNA binding activity. Involved in determination of adult lifespan and negative regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in hypodermis and rectum. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xrn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (14068907..14089877)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative RNA polymerase II nuclear localization protein SLC7A6OS Neighboring gene LEM protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Collagen Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Bossé GD, et al. Mol Cell, 2013 Apr 25. PMID 23541767, Free PMC Article
    2. Target-mediated protection of endogenous microRNAs in C. elegans. Chatterjee S, et al. Dev Cell, 2011 Mar 15. PMID 21397849
    3. The 5'-3' exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis. Newbury S, et al. RNA, 2004 Jan. PMID 14681585, Free PMC Article
    4. The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development. Jones CI, et al. Wiley Interdiscip Rev RNA, 2012 Jul-Aug. PMID 22383165
    5. Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. Boag PR, et al. J Cell Biol, 2008 Aug 11. PMID 18695045, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-3' exoribonuclease 1
    NP_496945.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14068907..14089877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064544.6 → NP_496945.3  5'-3' exoribonuclease 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496945.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BHK7
      Conserved Domains (3) summary
      COG5049
      Location:1 → 782
      XRN1; 5'-3' exonuclease [Replication, recombination and repair]
      pfam03159
      Location:1 → 226
      XRN_N; XRN 5'-3' exonuclease N-terminus
      cl19417
      Location:363 → 437
      FYDLN_acid; Protein of unknown function (FYDLN_acid)
    Nucleotide Protein
    Heading Accession and Version

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