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    mig-10 Abnormal cell migration protein 10 [ Caenorhabditis elegans ]

    Gene ID: 176168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-10
    Official Full Name
    Abnormal cell migration protein 10
    Primary source
    WormBase:WBGene00003243
    Locus tag
    CELE_F10E9.6
    See related
    AllianceGenome:WB:WBGene00003243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables SH3 domain binding activity. Involved in several processes, including egg-laying behavior; lamellipodium assembly; and nervous system development. Located in several cellular components, including growth cone membrane; neuronal cell body membrane; and presynaptic cytosol. Part of filamentous actin. Is expressed in several structures, including anal depressor muscle; intestine; neurons; rectal gland cell; and reproductive system. Orthologous to several human genes including RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (8279108..8305825)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development. Manser J, et al. Dev Biol, 1997 Apr 1. PMID 9142991
    2. The Lamellipodin homologue MIG-10 is not essential for dorsal intercalation in the embryonic epidermis of the C. elegans embryo. Serre JM, et al. MicroPubl Biol, 2022. PMID 35136857, Free PMC Article
    3. Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans. McShea MA, et al. Dev Biol, 2013 Jan 1. PMID 23022657, Free PMC Article
    4. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton. Stavoe AK, et al. J Cell Biol, 2012 Apr 2. PMID 22451697, Free PMC Article
    5. UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin. Quinn CC, et al. Curr Biol, 2006 May 9. PMID 16563765

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIG-10 stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
      Title: MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans.
    2. MIG-10 (lamellipodin), an effector of UNC-40 in neurons has functions independent of UNC-6/UNC-40. Unlike other UNC-40 effectors, its expression is regulated by FOS-1A, a transcription factor that promotes basement membrane breaching.
      Title: MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.
    3. these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways.
      Title: MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.
    4. MIG-10B interacts with Abl-interacting protein-1 (ABI-1)/Abi1, a component of the WAVE complex, to organize the actin cytoskeleton at presynaptic sites and instruct vesicle clustering through SNN-1/Synapsin
      Title: Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin.
    5. The CED-5 in turn signaled through CED-10/Rac1 and MIG-10/Lamellipodin to organize the actin cytoskeleton in presynaptic regions.
      Title: Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.
    6. Interaction between activated CED-10/Rac1 and MIG-10/lamellipodin triggers local cytoskeletal assembly and polarizes axon outgrowth.
      Title: CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.
    7. During neuronal development, mig-10 and the C. elegans Ena/VASP homolog unc-34 cooperate to guide axons toward UNC-6 (netrin) and away from SLT-1 (Slit).
      Title: MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin.
    8. Genetic analyses indicate that MIG-10/RIAM/lamellipodin functions downstream of the attractive guidance cue UNC-6/netrin and the repulsive guidance cue SLT-1/slit to direct the ventral migration of the AVM and PVM axons in C. elegans.
      Title: UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.
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    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of filamentous actin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Abnormal cell migration protein 10
    NP_001367746.1
    • Confirmed by transcript evidence
    NP_001370647.1
    • Confirmed by transcript evidence
    NP_498821.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8279108..8305825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379826.1 → NP_001367746.1  Abnormal cell migration protein 10 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34386, P34400, P34403, Q7JQ80, Q8WT53
      Conserved Domains (2) summary
      cd01259
      Location:452 → 575
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cl28922
      Location:321 → 406
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001382935.2 → NP_001370647.1  Abnormal cell migration protein 10 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd01259
      Location:340 → 463
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16138
      Location:209 → 294
      RA_MRL_MIG10; Ras-associating (RA) domain found in Caenorhabditis elegans abnormal cell migration protein 10 (MIG-10) and similar proteins

    3. NM_066420.6 → NP_498821.2  Abnormal cell migration protein 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498821.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34400
      Conserved Domains (3) summary
      cd01259
      Location:323 → 446
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:328 → 436
      PH; PH domain
      cl00155
      Location:196 → 275
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34400.3

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