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    bli-3 Dual oxidase 1 [ Caenorhabditis elegans ]

    Gene ID: 171608, updated on 9-Dec-2024

    Summary

    Official Symbol
    bli-3
    Official Full Name
    Dual oxidase 1
    Primary source
    WormBase:WBGene00000253
    Locus tag
    CELE_F56C11.1
    See related
    AllianceGenome:WB:WBGene00000253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic body morphogenesis. Located in plasma membrane. Is expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See bli-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (146486..154855, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LisH domain-containing protein Neighboring gene NAD(P)H oxidase (H2O2-forming) Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene SSD domain-containing protein Neighboring gene Carboxylic ester hydrolase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD(P)H oxidase H2O2-forming activity  
    enables NAD(P)H oxidase H2O2-forming activity PubMed 
    enables NADH oxidase H202-forming activity  
    enables NADPH oxidase H202-forming activity  
    enables heme binding PubMed 
    enables heme binding  
    enables oxidoreductase activity  
    enables peroxidase activity PubMed 
    enables peroxidase activity  
    enables superoxide-generating NAD(P)H oxidase activity  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification  
    involved_in collagen and cuticulin-based cuticle development PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle PubMed 
    involved_in defense response  
    involved_in defense response to Gram-positive bacterium PubMed 
    involved_in defense response to fungus PubMed 
    involved_in hydrogen peroxide catabolic process  
    involved_in nematode larval development PubMed 
    involved_in post-embryonic body morphogenesis PubMed 
    involved_in post-embryonic body morphogenesis PubMed 
    involved_in response to oxidative stress  
    involved_in response to oxidative stress PubMed 
    involved_in superoxide anion generation  
    Component Evidence Code Pubs
    part_of NADPH oxidase complex  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Dual oxidase 1
    NP_490686.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      146486..154855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058285.5 → NP_490686.3  Dual oxidase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490686.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61213, Q9NH90
      Conserved Domains (5) summary
      cd06186
      Location:1218 → 1402
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:31 → 586
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      COG5126
      Location:784 → 932
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam01794
      Location:1035 → 1176
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03098
      Location:28 → 542
      An_peroxidase; Animal haem peroxidase
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