U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    spe-6 Serine/threonine-protein kinase spe-6 [ Caenorhabditis elegans ]

    Gene ID: 176582, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    spe-6
    Official Full Name
    Serine/threonine-protein kinase spe-6
    Primary source
    WormBase:WBGene00004960
    Locus tag
    CELE_Y66D12A.20
    See related
    AllianceGenome:WB:WBGene00004960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in male meiosis chromosome separation; regulation of protein localization; and spermatid differentiation. Predicted to be active in cytoplasm and nucleus. Is expressed in sperm. [provided by Alliance of Genome Resources, Jan 2025]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See spe-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (11505488..11508930)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Mitochondrial import inner membrane translocase subunit Tim10 Neighboring gene TM2 domain-containing protein Y66D12A.21 Neighboring gene ArgoN domain-containing protein Neighboring gene Suppressor of spindle checkpoint defect 1 Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function. Peterson JJ, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849789, Free PMC Article
    2. The intrinsically disordered protein SPE-18 promotes localized assembly of MSP in Caenorhabditis elegans spermatocytes. Price KL, et al. Development, 2021 Mar 5. PMID 33558389, Free PMC Article
    3. The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency. Varkey JP, et al. Genetics, 1993 Jan. PMID 8417991, Free PMC Article
    4. A New Player in the Spermiogenesis Pathway of Caenorhabditis elegans. LaMunyon CW, et al. Genetics, 2015 Nov. PMID 26333688, Free PMC Article
    5. Changing synaptic specificities in the nervous system of Caenorhabditis elegans: differentiation of the DD motoneurons. Walthall WW, et al. J Neurobiol, 1993 Dec. PMID 8301267

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.
      Title: Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.
    2. Involved in early and late stages of sperm development in C. elegans. Strong alleles disrupt spermatocyte development. Weaker alleles cause precocious spermatid activation.
      Title: Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine-protein kinase spe-6
    NP_499482.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11505488..11508930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067081.4 → NP_499482.1  Serine/threonine-protein kinase spe-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95PZ9
      Conserved Domains (2) summary
      smart00220
      Location:26 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:25 → 293
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95PZ9.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools