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    sdc-1 C2H2-type domain-containing protein;Zinc finger protein sdc-1 [ Caenorhabditis elegans ]

    Gene ID: 181701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sdc-1
    Official Full Name
    C2H2-type domain-containing protein;Zinc finger protein sdc-1
    Primary source
    WormBase:WBGene00004745
    Locus tag
    CELE_F52E10.1
    See related
    AllianceGenome:WB:WBGene00004745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome; negative regulation of transcription by RNA polymerase II; and sex determination. Located in nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sdc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (16275763..16282534)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene ACT domain-containing protein Neighboring gene tRNA-Glu Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of sdc-1 in the sex determination and dosage compensation decisions in Caenorhabditis elegans. Villeneuve AM, et al. Genetics, 1990 Jan. PMID 2307356, Free PMC Article
    2. Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination. Hunter CP, et al. Nature, 1992 Feb 6. PMID 1741033
    3. A strategy to apply quantitative epistasis analysis on developmental traits. Labocha MK, et al. BMC Genet, 2017 May 15. PMID 28506208, Free PMC Article
    4. Function of the her-1 gene is required for maintenance of male differentiation in adult tissues of C. elegans. Schedin P, et al. Dev Genet, 1994. PMID 8062456
    5. The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals. Nusbaum C, et al. Genetics, 1989 Jul. PMID 2759421, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dosage compensation by hypoactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein;Zinc finger protein sdc-1
    NP_001360585.1
    • Confirmed by transcript evidence
    NP_510650.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16275763..16282534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373609.3 → NP_001360585.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WU44
      Conserved Domains (1) summary
      pfam00096
      Location:270 → 292
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_078249.8 → NP_510650.2  Zinc finger protein sdc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510650.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P24349, Q20672
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24349.2

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