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    sptl-3 Serine palmitoyltransferase 3 [ Caenorhabditis elegans ]

    Gene ID: 179884, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sptl-3
    Official Full Name
    Serine palmitoyltransferase 3
    Primary source
    WormBase:WBGene00011932
    Locus tag
    CELE_T22G5.5
    See related
    AllianceGenome:WB:WBGene00011932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sptl-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (13893325..13896415)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Fatty acid-binding protein homolog 8 Neighboring gene CYtochrome P450 family Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Goya ME, et al. Cell Rep, 2020 Jan 14. PMID 31940482, Free PMC Article
    2. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Zhang H, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926990, Free PMC Article
    3. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
    4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine C-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of serine palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine palmitoyltransferase 3
    NP_001256547.1
    • Partially confirmed by transcript evidence
    NP_001256548.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13893325..13896415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269618.3 → NP_001256547.1  Serine palmitoyltransferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVI6
      Conserved Domains (2) summary
      PLN02483
      Location:87 → 514
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:123 → 507
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

    2. NM_001269619.3 → NP_001256548.1  Serine palmitoyltransferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G307, Q9XVI6
      Conserved Domains (2) summary
      PLN02483
      Location:78 → 505
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:114 → 498
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVI6.2

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