usip-1 U6 snRNA-specific terminal uridylyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: usip-1
Official Full Name: U6 snRNA-specific terminal uridylyltransferase
Primary source: WormBase:WBGene00014124
Locus tag: CELE_ZK863.4
See related: AllianceGenome:WB:WBGene00014124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA uridylyltransferase activity. Involved in U6 snRNA 3'-end processing. Located in nucleoplasm. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See usip-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (12181501..12184194, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous USIP-1-U6 snRNA complexes lack the Lsm proteins that constitute the protein core of the U6 snRNP, but contain the U6 snRNP recycling factor SART3/B0035.12.
Title: The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK863.4 (e-PCR)
- UniSTS:310557

ZK863.5 (e-PCR)
- UniSTS:308322

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in U6 snRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: U6 snRNA-specific terminal uridylyltransferase

NP_506056.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12181501..12184194 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073655.9 → NP_506056.1 U6 snRNA-specific terminal uridylyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506056.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23652

Conserved Domains (2) summary

pfam03828
Location:382 → 437

PAP_assoc; Cid1 family poly A polymerase

cl11966
Location:142 → 297

NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins