phb-1 Mitochondrial prohibitin complex protein 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: phb-1
Official Full Name: Mitochondrial prohibitin complex protein 1
Primary source: WormBase:WBGene00004014
Locus tag: CELE_Y37E3.9
See related: AllianceGenome:WB:WBGene00004014
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including defecation; regulation of nematode pharyngeal pumping; and regulation of oxidative phosphorylation. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Is expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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The p38MAPK/ATF-7 immune pathway is triggered by mitochondrial complex I dysfunction.
Title: The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective.
mitochondrial prohibitin complex promotes longevity by modulating mitochondrial function and fat metabolism in the nematode Caenorhabditis elegans
Title: Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans.
role in embryonic viability and germline function
Title: The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial prohibitin complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_490929.1

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The following sections contain reference sequences that belong to a specific genome build. Explain