pfk-1.1 ATP-dependent 6-phosphofructokinase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pfk-1.1
Official Full Name: ATP-dependent 6-phosphofructokinase 1
Primary source: WormBase:WBGene00022199
Locus tag: CELE_Y71H10A.1
See related: AllianceGenome:WB:WBGene00022199
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 6-phosphofructokinase activity and fructose-6-phosphate binding activity. Predicted to be involved in canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and fructose 6-phosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be part of 6-phosphofructokinase complex. Is expressed in germ line; hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to several human genes including PFKL (phosphofructokinase, liver type) and PFKM (phosphofructokinase, muscle). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pfk-1.1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (2940872..2945485)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y71H10A.1 (e-PCR)
- UniSTS:307147

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 6-phosphofructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphofructokinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fructose-6-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 6-phosphofructokinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent 6-phosphofructokinase 1

NP_741738.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2940872..2945485

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171643.6 → NP_741738.1 ATP-dependent 6-phosphofructokinase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741738.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95X24, Q9TZL8

Conserved Domains (2) summary

TIGR02478
Location:46 → 793

6PF1K_euk; 6-phosphofructokinase, eukaryotic type

cl00204
Location:44 → 792

PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...