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    acbp-1 Acyl-CoA-binding protein homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 172071, updated on 27-Dec-2024

    Summary

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    Official Symbol
    acbp-1
    Official Full Name
    Acyl-CoA-binding protein homolog 1
    Primary source
    WormBase:WBGene00016655
    Locus tag
    CELE_C44E4.6
    See related
    AllianceGenome:WB:WBGene00016655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Involved in determination of adult lifespan and lipid storage. Is expressed in intestine. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to several human genes including DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acbp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (4635746..4636379, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NudC domain-containing protein 1 Neighboring gene UBR-type domain-containing protein Neighboring gene ncRNA Neighboring gene Lupus La protein Neighboring gene ncRNA Neighboring gene Aspartate aminotransferase Neighboring gene RanBP2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans. Elle IC, et al. Biochem J, 2011 Jul 15. PMID 21539519
    2. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    3. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Acyl-CoA-binding protein homolog 1
    NP_491412.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4635746..4636379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059011.8 → NP_491412.1  Acyl-CoA-binding protein homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01805
      Conserved Domains (1) summary
      cd00435
      Location:1 → 85
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01805.1

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