U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

    Gene ID: 8202, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NCOA3provided by HGNC
    Official Full Name
    nuclear receptor coactivator 3provided by HGNC
    Primary source
    HGNC:HGNC:7670
    See related
    Ensembl:ENSG00000124151 MIM:601937; AllianceGenome:HGNC:7670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
    Summary
    The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
    Annotation information
    Note: RAC3 (Gene ID: 5881) and NCOA3 (Gene ID: 8202) share the RAC3 symbol/alias in common. RAC3 is a widely used alternative name for nuclear receptor coactivator 3 (NCOA3), which can be confused with the official symbol for ras-related C3 botulinum toxin substrate 3 (RAC3). [06 Jul 2018]
    Expression
    Ubiquitous expression in lymph node (RPKM 20.8), placenta (RPKM 19.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NCOA3 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47501887..47656872)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49240095..49395274)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130631..46285616)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12979 Neighboring gene RNA, U6 small nuclear 497, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr20.2047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12980 Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46152763-46153530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46158187-46158687 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:46190110-46190292 Neighboring gene MPRA-validated peak4234 silencer Neighboring gene ribosomal protein S3A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46276897-46277614 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46277615-46278332 Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46293563-46294548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46294549-46295532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46303203-46304168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46307531-46308031 Neighboring gene sulfatase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46316712-46317262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46317263-46317814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46326206-46326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339340-46339840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339841-46340341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381087-46381588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381589-46382088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386138-46386895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386896-46387654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46387655-46388411 Neighboring gene NANOG hESC enhancer GRCh37_chr20:46390145-46390683 Neighboring gene Sharpr-MPRA regulatory region 8498 Neighboring gene uncharacterized LOC124904922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18007 Neighboring gene uncharacterized LOC124904920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18008

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Association of NCOA3 polymorphisms with breast cancer risk. Burwinkel B, et al. Clin Cancer Res, 2005 Mar 15. PMID 15788663
    2. Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma. Li M, et al. Oncotarget, 2016 May 17. PMID 27105488, Free PMC Article
    3. Protein expressions of AIB1, p53 and Bcl-2 in epithelial ovarian cancer and their correlations with the clinical pathological features and prognosis. Liang M, et al. Eur Rev Med Pharmacol Sci, 2018 Aug. PMID 30178833
    4. NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression. Zhang B, et al. Cell Physiol Biochem, 2018. PMID 30261507
    5. SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. Xu FP, et al. Cancer Lett, 2007 Jan 8. PMID 16458427

    See all (430) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy.
      Title: Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy.
    2. Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis.
      Title: Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis.
    3. ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.
      Title: ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.
    4. NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways.
      Title: NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways.
    5. PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients.
      Title: PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients.
    6. Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene.
      Title: Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene.
    7. FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
      Title: FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
    8. An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.
      Title: An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.
    9. Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer.
      Title: Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer.
    10. PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.
      Title: PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (219)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
    EBI GWAS Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
    tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
    nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC141848

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell dedifferentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor transactivation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vitamin D receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear receptor coactivator 3
    Names
    CBP-interacting protein
    amplified in breast cancer 1 protein
    class E basic helix-loop-helix protein 42
    receptor-associated coactivator 3
    steroid receptor coactivator protein 3
    thyroid hormone receptor activator molecule 1
    NP_001167558.1
    NP_001167559.1
    NP_006525.2
    NP_858045.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016810.2 RefSeqGene

      Range
      5002..159987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001174087.2 → NP_001167558.1  nuclear receptor coactivator 3 isoform c

      See identical proteins and their annotated locations for NP_001167558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
      Source sequence(s)
      AL021394, AL034418, AL353777
      UniProtKB/TrEMBL
      Q569F6
      Conserved Domains (8) summary
      smart00091
      Location:116 → 173
      PAS; PAS domain
      cd18949
      Location:29 → 101
      bHLH-PAS_NCoA3_SRC3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 3 (NCoA-3) and similar proteins
      pfam07469
      Location:1290 → 1347
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1045 → 1091
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:616 → 704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265 → 375
      PAS_11; PAS domain
      pfam16279
      Location:723 → 810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459 → 572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    2. NM_001174088.2 → NP_001167559.1  nuclear receptor coactivator 3 isoform d

      See identical proteins and their annotated locations for NP_001167559.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
      Source sequence(s)
      AL021394, AL034418, AL353777
      Consensus CDS
      CCDS54472.1
      UniProtKB/TrEMBL
      Q0IIN7
      Related
      ENSP00000361065.3, ENST00000371997.3
      Conserved Domains (9) summary
      smart00353
      Location:34 → 88
      HLH; helix loop helix domain
      smart00091
      Location:116 → 173
      PAS; PAS domain
      pfam00989
      Location:117 → 215
      PAS; PAS fold
      pfam07469
      Location:1282 → 1339
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1040 → 1087
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:630 → 714
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265 → 385
      PAS_11; PAS domain
      pfam16279
      Location:733 → 820
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:469 → 582
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    3. NM_006534.4 → NP_006525.2  nuclear receptor coactivator 3 isoform b

      See identical proteins and their annotated locations for NP_006525.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AL021394, AL034418, AL353777
      Consensus CDS
      CCDS13406.1
      UniProtKB/TrEMBL
      Q0IIN7
      Related
      ENSP00000361073.1, ENST00000372004.7
      Conserved Domains (9) summary
      smart00353
      Location:34 → 88
      HLH; helix loop helix domain
      smart00091
      Location:116 → 173
      PAS; PAS domain
      pfam07469
      Location:1287 → 1344
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1045 → 1092
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:620 → 704
      SRC-1; Steroid receptor coactivator
      pfam09606
      Location:1077 → 1364
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14598
      Location:265 → 375
      PAS_11; PAS domain
      pfam16279
      Location:723 → 810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459 → 572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    4. NM_181659.3 → NP_858045.1  nuclear receptor coactivator 3 isoform a

      See identical proteins and their annotated locations for NP_858045.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL021394, AL034418, AL353777
      Consensus CDS
      CCDS13407.1
      UniProtKB/Swiss-Prot
      A4LAZ5, Q0VF45, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7, Q9Y6Q9
      UniProtKB/TrEMBL
      A8K0W8
      Related
      ENSP00000361066.3, ENST00000371998.8
      Conserved Domains (9) summary
      smart00353
      Location:34 → 88
      HLH; helix loop helix domain
      smart00091
      Location:116 → 173
      PAS; PAS domain
      pfam00989
      Location:117 → 215
      PAS; PAS fold
      pfam07469
      Location:1291 → 1348
      DUF1518; Domain of unknown function (DUF1518)
      pfam08815
      Location:1045 → 1092
      Nuc_rec_co-act; Nuclear receptor coactivator
      pfam08832
      Location:620 → 704
      SRC-1; Steroid receptor coactivator
      pfam14598
      Location:265 → 375
      PAS_11; PAS domain
      pfam16279
      Location:723 → 810
      DUF4927; Domain of unknown function (DUF4927)
      pfam16665
      Location:459 → 572
      NCOA_u2; Unstructured region on nuclear receptor coactivator protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      47501887..47656872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      49240095..49395274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools