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    gcy-6 Receptor-type guanylate cyclase gcy-6 [ Caenorhabditis elegans ]

    Gene ID: 191644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-6
    Official Full Name
    Receptor-type guanylate cyclase gcy-6
    Primary source
    WormBase:WBGene00001533
    Locus tag
    CELE_B0024.6
    See related
    AllianceGenome:WB:WBGene00001533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including chemosensory behavior; positive regulation of calcium-mediated signaling; and response to magnesium ion. Predicted to be active in plasma membrane. Is expressed in ASEL. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (10308291..10314053, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CUB_2 domain-containing protein Neighboring gene Crescerin-like protein che-12 Neighboring gene ncRNA Neighboring gene Thioredoxin;putative thioredoxin-2 Neighboring gene TUG ubiquitin-like domain-containing protein Neighboring gene Putative pseudouridine synthase B0024.11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights on the functions of the guanylyl cyclase receptors. Wedel BJ, et al. FEBS Lett, 1997 Jun 23. PMID 9247117
    2. The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans. Pierce-Shimomura JT, et al. Nature, 2001 Apr 5. PMID 11287956
    3. The C. elegans ceh-36 gene encodes a putative homemodomain transcription factor involved in chemosensory functions of ASE and AWC neurons. Koga M, et al. J Mol Biol, 2004 Feb 20. PMID 15095973
    4. Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases. Ortiz CO, et al. Curr Biol, 2009 Jun 23. PMID 19523832, Free PMC Article
    5. A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans. Johnston RJ, et al. Nature, 2003 Dec 18. PMID 14685240

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to magnesium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to magnesium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-6
    NP_001294696.1
    • Partially confirmed by transcript evidence
    NP_505650.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10308291..10314053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073249.3 → NP_505650.3  Receptor-type guanylate cyclase gcy-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505650.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      N1NVB7
      Conserved Domains (6) summary
      cd06352
      Location:29 → 441
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:854 → 1044
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:881 → 1066
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:53 → 420
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:843 → 875
      HNOBA; Heme NO binding associated
      cl21453
      Location:581 → 818
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001307767.1 → NP_001294696.1  Receptor-type guanylate cyclase gcy-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      N1NVB7, Q9XVV4
      Conserved Domains (6) summary
      cd06352
      Location:29 → 445
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:858 → 1048
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:885 → 1070
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:57 → 424
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:847 → 879
      HNOBA; Heme NO binding associated
      cl21453
      Location:585 → 822
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    N1NVB7.1

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