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    inx-20 Innexin [ Caenorhabditis elegans ]

    Gene ID: 188818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-20
    Official Full Name
    Innexin
    Primary source
    WormBase:WBGene00002142
    Locus tag
    CELE_T23H4.1
    See related
    AllianceGenome:WB:WBGene00002142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in gap junction and plasma membrane. Is expressed in pharyngeal cell and rectal valve cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (9874698..9879218)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tr-type G domain-containing protein Neighboring gene NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49 Neighboring gene Nuclear hormone receptor family member nhr-69 Neighboring gene tRNA-Glu Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans innexin INX-20 regulates nociceptive behavioral sensitivity. Chaubey AH, et al. Genetics, 2023 Apr 6. PMID 36753530, Free PMC Article
    2. Aversive Behavior in the Nematode C. elegans Is Modulated by cGMP and a Neuronal Gap Junction Network. Krzyzanowski MC, et al. PLoS Genet, 2016 Jul. PMID 27459302, Free PMC Article
    3. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655
    4. The role of gap junctions in Caenorhabditis elegans oocyte maturation and fertilization. Whitten SJ, et al. Dev Biol, 2007 Jan 15. PMID 16982048
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin
    NP_001251235.1
    • Partially confirmed by transcript evidence
    NP_001251236.1
    • Confirmed by transcript evidence
    NP_001251237.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9874698..9879218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264307.3 → NP_001251236.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGL4
      Conserved Domains (1) summary
      pfam00876
      Location:30 → 388
      Innexin; Innexin

    2. NM_001264306.2 → NP_001251235.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91827
      Conserved Domains (1) summary
      pfam00876
      Location:45 → 403
      Innexin; Innexin

    3. NM_001264308.4 → NP_001251237.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCJ1
      Conserved Domains (1) summary
      pfam00876
      Location:19 → 377
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version

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