nsf-1 Vesicle-fusing ATPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nsf-1
Official Full Name: Vesicle-fusing ATPase
Primary source: WormBase:WBGene00003818
Locus tag: CELE_H15N14.2
See related: AllianceGenome:WB:WBGene00003818
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in cytoplasm. Predicted to be active in Golgi stack. Is expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nsf-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 13

Sequence:: Chromosome: I; NC_003279.8 (7766532..7772231, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nsf-1 is required cell-autonomously in the uterine anchor cell for its fusion with the uterine-seam cell
Title: N-ethylmaleimide sensitive factor is required for fusion of the C. elegans uterine anchor cell.
p97/VCP/Cdc48p homologues, AAA chaperones, may play a protective role in polyQ aggregation
Title: Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1014.1 (e-PCR)
- UniSTS:310398

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in SNARE complex disassembly	IEA Inferred from Electronic Annotation more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vesicle-fusing ATPase

NP_001076603.1

Confirmed by transcript evidence

NP_001076604.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7766532..7772231 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083134.4 → NP_001076603.1 Vesicle-fusing ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076603.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94392

Conserved Domains (5) summary

cd00009
Location:609 → 746

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:331 → 476

AAA; ATPases associated with a variety of cellular activities

smart01072
Location:174 → 222

CDC48_2; Cell division protein 48 (CDC48) domain 2

smart01073
Location:68 → 147

CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

pfam00004
Location:333 → 474

AAA; ATPase family associated with various cellular activities (AAA)
NM_001083135.5 → NP_001076604.1 Vesicle-fusing ATPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076604.1

Status: REVIEWED

UniProtKB/TrEMBL

Q09EE7

Conserved Domains (5) summary

cd00009
Location:543 → 680

AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

smart00382
Location:265 → 410

AAA; ATPases associated with a variety of cellular activities

smart01072
Location:108 → 156

CDC48_2; Cell division protein 48 (CDC48) domain 2

smart01073
Location:2 → 81

CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

pfam00004
Location:267 → 408

AAA; ATPase family associated with various cellular activities (AAA)