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    dpy-30 Dosage compensation protein dpy-30 [ Caenorhabditis elegans ]

    Gene ID: 179671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpy-30
    Official Full Name
    Dosage compensation protein dpy-30
    Primary source
    WormBase:WBGene00001088
    Locus tag
    CELE_ZK863.6
    See related
    AllianceGenome:WB:WBGene00001088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including dosage compensation by hypoactivation of X chromosome; nematode male tail tip morphogenesis; and transdifferentiation. Located in nucleus. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpy-30 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (12191519..12192177)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene ncRNA Neighboring gene RNA-binding protein rnp-1 Neighboring gene Uncharacterized protein Neighboring gene Transketolase-like pyrimidine-binding domain-containing protein;putative 2-oxoadipate dehydrogenase complex component E1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans dosage compensation complex mediates interphase X chromosome compaction. Lau AC, et al. Epigenetics Chromatin, 2014. PMID 25400696, Free PMC Article
    2. An MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression. Pferdehirt RR, et al. Genes Dev, 2011 Mar 1. PMID 21363964, Free PMC Article
    3. Single-copy insertion of transgenes in Caenorhabditis elegans. Frøkjaer-Jensen C, et al. Nat Genet, 2008 Nov. PMID 18953339, Free PMC Article
    4. SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans. Yücel D, et al. Dev Biol, 2014 Aug 15. PMID 24882710
    5. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Wolkow CA, et al. Science, 2000 Oct 6. PMID 11021802

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPY-30 and HTZ-1 have unique functions in dosage compensation complex localization, both of which are largely independent of H3K4 methylation
      Title: Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in dosage compensation by hypoactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dosage compensation protein dpy-30
    NP_506058.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12191519..12192177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073657.8 → NP_506058.1  Dosage compensation protein dpy-30 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10661
      Conserved Domains (1) summary
      pfam05186
      Location:69 → 110
      Dpy-30; Dpy-30 motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10661.1

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