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    tbc-9 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-9
    Official Full Name
    Rab-GAP TBC domain-containing protein
    Primary source
    WormBase:WBGene00012868
    Locus tag
    CELE_Y45F10A.6
    See related
    AllianceGenome:WB:WBGene00012868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to several human genes including TBC1D8 (TBC1 domain family member 8); TBC1D8B (TBC1 domain family member 8B); and TBC1D9 (TBC1 domain family member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (13476932..13502856, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene non-specific serine/threonine protein kinase Neighboring gene RING-type domain-containing protein Neighboring gene Glycoprotein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DEP domain-containing protein;DUF547 domain-containing protein Neighboring gene Neuropeptide-Like Protein Neighboring gene putative selenide, water dikinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans. Takagaki N, et al. EMBO Rep, 2020 Mar 4. PMID 32009302, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab-GAP TBC domain-containing protein
    NP_001122812.1
    • Confirmed by transcript evidence
    NP_001263806.1
    • Confirmed by transcript evidence
    NP_001263807.1
    • Confirmed by transcript evidence
    NP_001263808.1
    • Confirmed by transcript evidence
    NP_001293954.1
    • Confirmed by transcript evidence
    NP_502598.2
    • Confirmed by transcript evidence
    NP_502599.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13476932..13502856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307025.4 → NP_001293954.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACS9
      Conserved Domains (3) summary
      smart00164
      Location:489 → 695
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:309 → 406
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:154 → 253
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

    2. NM_001129340.5 → NP_001122812.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE94
      Conserved Domains (3) summary
      smart00164
      Location:489 → 695
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:309 → 406
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:154 → 253
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

    3. NM_070197.6 → NP_502598.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502598.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBE2
      Conserved Domains (3) summary
      smart00164
      Location:489 → 695
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:309 → 406
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:154 → 253
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

    4. NM_070198.5 → NP_502599.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502599.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBY2
      Conserved Domains (3) summary
      smart00164
      Location:489 → 695
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:309 → 406
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:154 → 253
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1

    5. NM_001276879.3 → NP_001263808.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ESI6
      Conserved Domains (3) summary
      smart00164
      Location:300 → 506
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:120 → 217
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain

    6. NM_001276878.3 → NP_001263807.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ESB8
      Conserved Domains (3) summary
      smart00164
      Location:300 → 506
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:120 → 217
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain

    7. NM_001276877.3 → NP_001263806.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8F7X2
      Conserved Domains (3) summary
      smart00164
      Location:300 → 506
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:120 → 217
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
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