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    ugt-66 UDP-glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 182814, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ugt-66
    Official Full Name
    UDP-glucuronosyltransferase
    Primary source
    WormBase:WBGene00016013
    Locus tag
    CELE_C23G10.6
    See related
    AllianceGenome:WB:WBGene00016013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Orthologous to several human genes including UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus); UGT2A3 (UDP glucuronosyltransferase family 2 member A3); and UGT2B10 (UDP glucuronosyltransferase family 2 member B10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ugt-66 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (6192116..6194580, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box associated domain-containing protein Neighboring gene ncRNA Neighboring gene putative tRNA (uracil-O(2)-)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of UDP-Glycosyltransferase (ugt) Genes in Detoxification and Glycosylation of 1-Hydroxyphenazine (1-HP) in Caenorhabditis elegans. Asif MZ, et al. Chem Res Toxicol, 2024 Apr 15. PMID 38488606, Free PMC Article
    2. UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. Matoušková P, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30293057, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase
    NP_498344.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6192116..6194580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065943.4 → NP_498344.3  UDP-glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498344.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GYR7
      Conserved Domains (2) summary
      pfam00201
      Location:22 → 530
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
      cl10013
      Location:222 → 477
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    Nucleotide Protein
    Heading Accession and Version

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