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    nhr-80 Nuclear hormone receptor family member nhr-80 [ Caenorhabditis elegans ]

    Gene ID: 175167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-80
    Official Full Name
    Nuclear hormone receptor family member nhr-80
    Primary source
    WormBase:WBGene00003670
    Locus tag
    CELE_H10E21.3
    See related
    AllianceGenome:WB:WBGene00003670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of fatty acid metabolic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-80 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (11985..14869, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Transposase Neighboring gene EF-hand domain-containing protein Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Seah NE, et al. Autophagy, 2016. PMID 26671266, Free PMC Article
    2. Graphene oxide nano-bio interaction induces inhibition of spermatogenesis and disturbance of fatty acid metabolism in the nematode Caenorhabditis elegans. Kim Y, et al. Toxicology, 2018 Dec 1. PMID 30218681
    3. Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8. Tillman MC, et al. Sci Rep, 2019 Jul 10. PMID 31292465, Free PMC Article
    4. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Brejning J, et al. Aging Cell, 2014 Feb. PMID 24286221, Free PMC Article
    5. Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. Goudeau J, et al. PLoS Biol, 2011 Mar. PMID 21423649, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the NHR-80 pathway participates in the mechanism of longevity extension through depletion of the germ line.
      Title: Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-80
    NP_497126.1
    • Confirmed by transcript evidence
    NP_871630.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11985..14869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064725.7 → NP_497126.1  Nuclear hormone receptor family member nhr-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76668
      Conserved Domains (2) summary
      smart00399
      Location:12 → 80
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:243 → 418
      HOLI; Ligand binding domain of hormone receptors

    2. NM_181901.2 → NP_871630.1  Nuclear hormone receptor family member nhr-80 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76668, Q8ITW8, Q9BJK7
      Conserved Domains (2) summary
      smart00399
      Location:30 → 98
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      smart00430
      Location:261 → 436
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ITW8.1

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