ben-1 Tubulin beta chain [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ben-1
Official Full Name: Tubulin beta chain
Primary source: WormBase:WBGene00000248
Locus tag: CELE_C54C6.2
See related: AllianceGenome:WB:WBGene00000248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity and structural molecule activity. Predicted to be a structural constituent of cytoskeleton. Involved in chemosensory behavior and egg-laying behavior. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in coelomocyte; epithelial cell; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6; congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa) and TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_497728.2

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The following sections contain reference sequences that belong to a specific genome build. Explain