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    nud-1 Nuclear migration protein nudC [ Caenorhabditis elegans ]

    Gene ID: 176754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nud-1
    Official Full Name
    Nuclear migration protein nudC
    Primary source
    WormBase:WBGene00003829
    Locus tag
    CELE_F53A2.4
    See related
    AllianceGenome:WB:WBGene00003829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity and unfolded protein binding activity. Involved in several processes, including GABAergic synaptic transmission; chaperone-mediated protein folding; and pronuclear migration. Predicted to be located in synapse. Predicted to be active in cytoplasm. Is expressed in gonad; hypodermis; intestine; and neurons. Used to study epilepsy and lissencephaly. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nud-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (13341527..13342608)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Phosphoprotein Neighboring gene Protein Dr1 Neighboring gene Eukaryotic translation initiation factor 4E-1;eIF-4F 25 kDa subunit Neighboring gene 3-ketoacyl-CoA thiolase, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Faircloth LM, et al. Cell Stress Chaperones, 2009 Jan. PMID 18626791, Free PMC Article
    2. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Aumais JP, et al. J Cell Sci, 2003 May 15. PMID 12679384
    3. Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for nuclear distribution element genes. Campeiro JD, et al. Neurochem Int, 2021 Jul. PMID 33872680
    4. Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia. Monte GG, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2019 Jun 8. PMID 30578843
    5. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe AL, et al. Dev Genes Evol, 2001 Sep. PMID 11685578

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear migration protein nudC
    NP_499749.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13341527..13342608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067348.8 → NP_499749.1  Nuclear migration protein nudC [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE74
      Conserved Domains (3) summary
      cd06492
      Location:161 → 247
      p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...
      PTZ00121
      Location:54 → 174
      PTZ00121; MAEBL; Provisional
      pfam14050
      Location:6 → 40
      Nudc_N; N-terminal conserved domain of Nudc
    Nucleotide Protein
    Heading Accession and Version

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