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    snrp-200 U5 small nuclear ribonucleoprotein 200 kDa helicase [ Caenorhabditis elegans ]

    Gene ID: 174901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snrp-200
    Official Full Name
    U5 small nuclear ribonucleoprotein 200 kDa helicase
    Primary source
    WormBase:WBGene00012896
    Locus tag
    CELE_Y46G5A.4
    See related
    AllianceGenome:WB:WBGene00012896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA helicase activity. Predicted to be involved in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Is expressed in excretory cell; gonad; head ganglion; intestine; and pharynx. Used to study retinitis pigmentosa 33. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 33. Orthologous to human SNRNP200 (small nuclear ribonucleoprotein U5 subunit 200). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snrp-200 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (12726963..12736910, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Heme O synthase Neighboring gene CRC domain-containing protein;Rab-GAP TBC domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5' splice site identity. Cartwright-Acar CH, et al. Nucleic Acids Res, 2022 Nov 11. PMID 36321655, Free PMC Article
    2. Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allow drug screens and identification of disease modifiers. Kukhtar D, et al. Hum Mol Genet, 2020 Mar 27. PMID 31919495
    3. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
    4. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. Gao K, et al. Elife, 2019 Jan 15. PMID 30642431, Free PMC Article
    5. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5' splice site identity.
      Title: A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5' splice site identity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    U5 small nuclear ribonucleoprotein 200 kDa helicase
    NP_001366952.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12726963..12736910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381632.2 → NP_001366952.1  U5 small nuclear ribonucleoprotein 200 kDa helicase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2G0
      Conserved Domains (5) summary
      smart00611
      Location:1808 → 2127
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:438 → 1234
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      PRK00254
      Location:1313 → 1878
      PRK00254; ski2-like helicase; Provisional
      cd18021
      Location:1319 → 1509
      DEXHc_Brr2_2; C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase
      pfam18149
      Location:254 → 359
      Helicase_PWI; N-terminal helicase PWI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2G0.1

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