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    epg-5 Ectopic P granules protein 5 [ Caenorhabditis elegans ]

    Gene ID: 3565794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-5
    Official Full Name
    Ectopic P granules protein 5
    Primary source
    WormBase:WBGene00016968
    Locus tag
    CELE_C56C10.12
    See related
    AllianceGenome:WB:WBGene00016968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in macroautophagy and negative regulation of autophagosome assembly. Located in cytoplasm. Is expressed in several structures, including body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in Vici syndrome. Orthologous to human EPG5 (ectopic P-granules 5 autophagy tethering factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    23
    Sequence:
    Chromosome: II; NC_003280.10 (6598344..6609365, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 33B Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Li W, et al. J Cell Biol, 2012 Apr 2. PMID 22451698, Free PMC Article
    2. Autophagy genes promote apoptotic cell corpse clearance. Zou W, et al. Autophagy, 2012 Aug. PMID 22653037
    3. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
    4. C. elegans screen identifies autophagy genes specific to multicellular organisms. Tian Y, et al. Cell, 2010 Jun 11. PMID 20550938
    5. O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Guo B, et al. Nat Cell Biol, 2014 Dec. PMID 25419848

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectopic P granules protein 5
    NP_001356411.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6598344..6609365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001369482.2 → NP_001356411.1  Ectopic P granules protein 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18892
    Nucleotide Protein
    Heading Accession and Version

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