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    epg-8 MRG domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    epg-8
    Official Full Name
    MRG domain-containing protein
    Primary source
    WormBase:WBGene00013695
    Locus tag
    CELE_Y106G6A.2
    See related
    AllianceGenome:WB:WBGene00013695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol 3-kinase regulator activity and protein-membrane adaptor activity. Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Is expressed in intestine; neurons; and pharyngeal muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See epg-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9931870..9934290, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Methyltranfer_dom domain-containing protein Neighboring gene START domain-containing protein;Steroidogenic acute regulatory-like protein 1 Neighboring gene BAR domain-containing protein Neighboring gene Dysbindin protein homolog Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans. Yang P, et al. Autophagy, 2011 Feb. PMID 21116129
    2. Insights into the Neuroprotective Potential of Epicatechin: Effects against Aβ-Induced Toxicity in Caenorhabditis elegans. Ayuda-Durán B, et al. Antioxidants (Basel), 2024 Jan 8. PMID 38247503, Free PMC Article
    3. C. elegans Blastomeres Clear the Corpse of the Second Polar Body by LC3-Associated Phagocytosis. Fazeli G, et al. Cell Rep, 2018 May 15. PMID 29768205
    4. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
    5. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome membrane docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of omegasome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MRG domain-containing protein
    NP_001251254.1
    • Confirmed by transcript evidence
    NP_001380108.1
    • Confirmed by transcript evidence
    NP_740908.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9931870..9934290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170914.6 → NP_740908.1  MRG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWQ4
      Conserved Domains (1) summary
      TIGR02169
      Location:101 → 221
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_001264325.3 → NP_001251254.1  MRG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UBJ1
      Conserved Domains (1) summary
      TIGR02169
      Location:20 → 140
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. NM_001392913.1 → NP_001380108.1  MRG domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UBJ2

    RNA

    1. NR_002352.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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