R74.7 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R74.7
Official Full Name: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Primary source: WormBase:WBGene00011281
Locus tag: CELE_R74.7
See related: AllianceGenome:WB:WBGene00011281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable S-adenosyl-L-methionine binding activity; tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity; and tRNA (guanine) methyltransferase activity. Predicted to be involved in cytoplasmic translation; neurogenesis; and wobble position ribose methylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in body wall musculature; intestine; and tail. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 9. Orthologous to human FTSJ1 (FtsJ RNA 2'-O-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R74.7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (4204429..4205813)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R74.7 (e-PCR)
- UniSTS:310582

R74.6 (e-PCR)
- UniSTS:307885

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA (cytidine) methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine) methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA nucleoside ribose methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA nucleoside ribose methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in wobble position ribose methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

NP_497843.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4204429..4205813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065442.7 → NP_497843.1 Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497843.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22031

Conserved Domains (1) summary

COG0293
Location:3 → 204

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]