U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ger-1 GDP-L-fucose synthase [ Caenorhabditis elegans ]

    Gene ID: 187512, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ger-1
    Official Full Name
    GDP-L-fucose synthase
    Primary source
    WormBase:WBGene00019813
    Locus tag
    CELE_R01H2.5
    See related
    AllianceGenome:WB:WBGene00019813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP-L-fucose synthase activity. Involved in GDP-L-fucose biosynthetic process. Is expressed in pharynx; seam cell; and spermatheca. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ger-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7065439..7067477, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene LDL receptor repeat-containing protein egg-2 Neighboring gene DUF4806 domain-containing protein;SERPIN domain-containing protein Neighboring gene Ovule protein Neighboring gene Ubiquitin-conjugating enzyme E2 ubc-18 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. Rhomberg S, et al. FEBS J, 2006 May. PMID 16650000
    2. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Butschi A, et al. PLoS Pathog, 2010 Jan. PMID 20062796, Free PMC Article
    3. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article
    4. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning, purification and charactrization of ger-1
      Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-L-fucose synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-L-fucose synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-L-fucose synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response HEP PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    GDP-L-fucose synthase
    NP_498540.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7065439..7067477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066139.5 → NP_498540.1  GDP-L-fucose synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EER4
      Conserved Domains (2) summary
      cd05239
      Location:3 → 306
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
      pfam01370
      Location:4 → 235
      Epimerase; NAD dependent epimerase/dehydratase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EER4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous