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    snrp-27 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [ Caenorhabditis elegans ]

    Gene ID: 172652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snrp-27
    Official Full Name
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    Primary source
    WormBase:WBGene00011035
    Locus tag
    CELE_R05D11.7
    See related
    AllianceGenome:WB:WBGene00011035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Orthologous to human SNRNP27 (small nuclear ribonucleoprotein U4/U6.U5 subunit 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snrp-27 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (8601355..8602035)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Partner of xrn-2 protein 1 Neighboring gene putative ATP-dependent RNA helicase DDX52 Neighboring gene DFDF domain-containing protein Neighboring gene Vesicle transport protein Neighboring gene putative isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNRP-27, the C. elegans homolog of the tri-snRNP 27K protein, has a role in 5' splice site positioning in the spliceosome. Zahler AM, et al. RNA, 2018 Oct. PMID 30006499, Free PMC Article
    2. A role for SNU66 in maintaining 5' splice site identity during spliceosome assembly. Sarka K, et al. RNA, 2024 May 16. PMID 38443114, Free PMC Article
    3. A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly. Dassah M, et al. Genetics, 2009 Jul. PMID 19380478, Free PMC Article
    4. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Garrido-Lecca A, et al. Mol Cell Biol, 2010 Aug. PMID 20498277, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for SNU66 in maintaining 5' splice site identity during spliceosome assembly.
      Title: A role for SNU66 in maintaining 5' splice site identity during spliceosome assembly.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
    NP_001369953.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8601355..8602035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383485.2 → NP_001369953.1  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21739
      Conserved Domains (1) summary
      pfam08648
      Location:100 → 154
      DUF1777; Protein of unknown function (DUF1777)
    Nucleotide Protein
    Heading Accession and Version

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